Enhancement of NMDA-induced increases in levels of endogenous adenosine by adenosine deaminase and adenosine transport inhibition in rat striatum
Identifieur interne : 004050 ( Main/Exploration ); précédent : 004049; suivant : 004051Enhancement of NMDA-induced increases in levels of endogenous adenosine by adenosine deaminase and adenosine transport inhibition in rat striatum
Auteurs : Suzanne M. Delaney [Canada] ; Jonathan D. Geiger [Canada]Source :
- Brain Research [ 0006-8993 ] ; 1995.
English descriptors
- KwdEn :
Abstract
Abstract: Unilateral microinjection of N-methyl-d-aspartate (NMDA) into striatum of rats subsequently killed by high-energy focused microwave irradiation significantly increased in vivo levels of endogenous adenosine. At a dose of 25 nmol NMDA, levels of adenosine in injected striata were 263% of levels in uninjected contralateral striata. An inhibitor of adenosine deaminase (deoxycoformycin, DCF) in combination with an inhibitor of adenosine transport (dilazep, DLZP) at a dose that did not affect levels of endogenous adenosine, potentiated NMDA-induced increases in adenosine levels to 426% of contralateral striata. In the presence of DCF and DLZP, NMDA dose-dependently increased levels of adenosine (% of contralateral striatum) from 166% at 10 nmol to 622% at 100 nmol. NMDA-induced increases in levels of endogenous adenosine were completely blocked by prior administration of the NMDA receptor antagonist MK 801 (dizocilpine). Inhibitors of adenosine metabolism and transport may provide therapeutic benefit by potentiating excitatory amino acid-induced increases in levels of endogenous adenosine in vivo.
Url:
DOI: 10.1016/0006-8993(95)01010-9
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001779
- to stream Istex, to step Curation: 001779
- to stream Istex, to step Checkpoint: 001A24
- to stream Main, to step Merge: 004772
- to stream Main, to step Curation: 004050
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Enhancement of NMDA-induced increases in levels of endogenous adenosine by adenosine deaminase and adenosine transport inhibition in rat striatum</title><author><name sortKey="Delaney, Suzanne M" sort="Delaney, Suzanne M" uniqKey="Delaney S" first="Suzanne M." last="Delaney">Suzanne M. Delaney</name></author><author><name sortKey="Geiger, Jonathan D" sort="Geiger, Jonathan D" uniqKey="Geiger J" first="Jonathan D." last="Geiger">Jonathan D. Geiger</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:A33A9BF5854FB7505F6EBC5A9824CB847AFF6BD9</idno><date when="1995" year="1995">1995</date><idno type="doi">10.1016/0006-8993(95)01010-9</idno><idno type="url">https://api-v5.istex.fr/document/A33A9BF5854FB7505F6EBC5A9824CB847AFF6BD9/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001779</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001779</idno><idno type="wicri:Area/Istex/Curation">001779</idno><idno type="wicri:Area/Istex/Checkpoint">001A24</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001A24</idno><idno type="wicri:doubleKey">0006-8993:1995:Delaney S:enhancement:of:nmda</idno><idno type="wicri:Area/Main/Merge">004772</idno><idno type="wicri:Area/Main/Curation">004050</idno><idno type="wicri:Area/Main/Exploration">004050</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Enhancement of NMDA-induced increases in levels of endogenous adenosine by adenosine deaminase and adenosine transport inhibition in rat striatum</title><author><name sortKey="Delaney, Suzanne M" sort="Delaney, Suzanne M" uniqKey="Delaney S" first="Suzanne M." last="Delaney">Suzanne M. Delaney</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>De[artment of Pharmacology and Therapeutics, University of Manitoba Faculty of Medicine, 770 Bannatyne Ave, Winnipeg, MB R3E 0W3</wicri:regionArea><wicri:noRegion>MB R3E 0W3</wicri:noRegion></affiliation></author><author><name sortKey="Geiger, Jonathan D" sort="Geiger, Jonathan D" uniqKey="Geiger J" first="Jonathan D." last="Geiger">Jonathan D. Geiger</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>De[artment of Pharmacology and Therapeutics, University of Manitoba Faculty of Medicine, 770 Bannatyne Ave, Winnipeg, MB R3E 0W3</wicri:regionArea><wicri:noRegion>MB R3E 0W3</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Canada</country></affiliation></author></analytic><monogr></monogr><series><title level="j">Brain Research</title><title level="j" type="abbrev">BRES</title><idno type="ISSN">0006-8993</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1995">1995</date><biblScope unit="volume">702</biblScope><biblScope unit="issue">1–2</biblScope><biblScope unit="page" from="72">72</biblScope><biblScope unit="page" to="76">76</biblScope></imprint><idno type="ISSN">0006-8993</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0006-8993</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenosine</term><term>Deoxycoformycin</term><term>Dilazep</term><term>Focused microwave sacrifice</term><term>Microinjection</term><term>NMDA</term><term>Striatum</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Unilateral microinjection of N-methyl-d-aspartate (NMDA) into striatum of rats subsequently killed by high-energy focused microwave irradiation significantly increased in vivo levels of endogenous adenosine. At a dose of 25 nmol NMDA, levels of adenosine in injected striata were 263% of levels in uninjected contralateral striata. An inhibitor of adenosine deaminase (deoxycoformycin, DCF) in combination with an inhibitor of adenosine transport (dilazep, DLZP) at a dose that did not affect levels of endogenous adenosine, potentiated NMDA-induced increases in adenosine levels to 426% of contralateral striata. In the presence of DCF and DLZP, NMDA dose-dependently increased levels of adenosine (% of contralateral striatum) from 166% at 10 nmol to 622% at 100 nmol. NMDA-induced increases in levels of endogenous adenosine were completely blocked by prior administration of the NMDA receptor antagonist MK 801 (dizocilpine). Inhibitors of adenosine metabolism and transport may provide therapeutic benefit by potentiating excitatory amino acid-induced increases in levels of endogenous adenosine in vivo.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Delaney, Suzanne M" sort="Delaney, Suzanne M" uniqKey="Delaney S" first="Suzanne M." last="Delaney">Suzanne M. Delaney</name></noRegion><name sortKey="Geiger, Jonathan D" sort="Geiger, Jonathan D" uniqKey="Geiger J" first="Jonathan D." last="Geiger">Jonathan D. Geiger</name><name sortKey="Geiger, Jonathan D" sort="Geiger, Jonathan D" uniqKey="Geiger J" first="Jonathan D." last="Geiger">Jonathan D. Geiger</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004050 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004050 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:A33A9BF5854FB7505F6EBC5A9824CB847AFF6BD9
|texte= Enhancement of NMDA-induced increases in levels of endogenous adenosine by adenosine deaminase and adenosine transport inhibition in rat striatum
}}
| This area was generated with Dilib version V0.6.29. |  |